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infinite}#os-agonists-antagonists-animation .antagonismAgonistAnimate{-webkit-animation:cellSideSide 7.2s ease-in-out infinite;animation:cellSideSide 7.2s ease-in-out infinite}@-webkit-keyframes cellUpDown{0%{margin-top:1.125rem}21%{margin-top:1.125rem}28%{margin-top:4.875rem}90%{margin-top:4.875rem}to{margin-top:1.125rem}}@keyframes cellUpDown{0%{margin-top:1.125rem}21%{margin-top:1.125rem}28%{margin-top:4.875rem}90%{margin-top:4.875rem}to{margin-top:1.125rem}}@-webkit-keyframes iconAnimate{0%{opacity:0}30%{opacity:0}37%{opacity:1}90%{opacity:1}to{opacity:0}}@keyframes iconAnimate{0%{opacity:0}30%{opacity:0}37%{opacity:1}90%{opacity:1}to{opacity:0}}@-webkit-keyframes arrowAnimate{0%{margin-top:0;opacity:0}30%{margin-top:-1.25rem;opacity:0}37%{margin-top:0;opacity:1}90%{margin-top:0;opacity:1}to{margin-top:0;opacity:0}}@keyframes arrowAnimate{0%{margin-top:0;opacity:0}30%{margin-top:-1.25rem;opacity:0}37%{margin-top:0;opacity:1}90%{margin-top:0;opacity:1}to{margin-top:0;opacity:0}}@-webkit-keyframes labelAnimate{0%{opacity:0}37%{opacity:0}45%{opacity:1}90%{opacity:1}to{opacity:0}}@keyframes labelAnimate{0%{opacity:0}37%{opacity:0}45%{opacity:1}90%{opacity:1}to{opacity:0}}@-webkit-keyframes cellSideSide{0%{left:calc(50% - 1.875rem);opacity:0}30%{left:calc(50% - 1.875rem);opacity:0}37%{left:50%;opacity:1}40%{left:calc(50% - .625rem)}90%{opacity:1}to{left:calc(50% - .625rem);opacity:0}}@keyframes cellSideSide{0%{left:calc(50% - 1.875rem);opacity:0}30%{left:calc(50% - 1.875rem);opacity:0}37%{left:50%;opacity:1}40%{left:calc(50% - .625rem)}90%{opacity:1}to{left:calc(50% - .625rem);opacity:0}}@media screen and (max-width:1024.9px){#os-agonists-antagonists-animation .agonist,#os-agonists-antagonists-animation .antagonist{margin-left:0 .3125rem}#os-agonists-antagonists-animation .antagonist{top:.375rem}@-webkit-keyframes cellUpDown{0%{margin-top:1.125rem}21%{margin-top:1.125rem}28%{margin-top:3.3125rem}90%{margin-top:3.3125rem}to{margin-top:1.125rem}}@keyframes cellUpDown{0%{margin-top:1.125rem}21%{margin-top:1.125rem}28%{margin-top:3.3125rem}90%{margin-top:3.3125rem}to{margin-top:1.125rem}}@-webkit-keyframes cellSideSide{0%{left:calc(50% - 1.875rem);opacity:0}30%{left:calc(50% - 1.875rem);opacity:0}37%{left:50%;opacity:1}40%{left:50%}90%{opacity:1}to{left:50%;opacity:0}}@keyframes cellSideSide{0%{left:calc(50% - 1.875rem);opacity:0}30%{left:calc(50% - 1.875rem);opacity:0}37%{left:50%;opacity:1}40%{left:50%}90%{opacity:1}to{left:50%;opacity:0}}}#os-agonists-antagonists-animation .greek-symbol{font-family:"Noto Serif",serif}.cmp-container-error-page{height:33.125rem;padding:4rem 1rem}.cmp-container-error-page .cmp-text{text-align:center}.cmp-container-error-page .cmp-text h2{margin:0}@media screen and (min-width:481px){.cmp-container-error-page{padding:4rem 2rem}}.cmp-container-type-header{font-family:p22-mackinac-pro,Serif}.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-item.logo{height:4rem;padding-left:0}.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id] .cmp-alks-common-jump-links-link-text{color:#3a495b;font-weight:700}.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id].active .cmp-alks-common-jump-links-link-text:after,.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id]:focus .cmp-alks-common-jump-links-link-text:after,.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id]:focus-visible .cmp-alks-common-jump-links-link-text:after,.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id]:hover .cmp-alks-common-jump-links-link-text:after{background-color:#3a495b;left:-2rem;width:calc(100% + 4rem)}@media screen and (max-width:1024.9px){.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id].active .cmp-alks-common-jump-links-link-text:after,.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id]:focus .cmp-alks-common-jump-links-link-text:after,.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id]:focus-visible .cmp-alks-common-jump-links-link-text:after,.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-link[data-jumplink-id]:hover .cmp-alks-common-jump-links-link-text:after{left:-.25rem;width:calc(100% + .5rem)}}.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .cmp-alks-common-jump-links-hamburger:after{-webkit-box-flex:0;background-image:url('data:image/svg+xml;utf8,');background-position:50%;background-repeat:no-repeat;content:"";display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-ms-flex:0 0 auto;flex:0 0 auto;height:1.25rem;text-indent:-9999px;width:1.25rem}.cmp-container-type-header:has(.cmp-alks-common-jump-links.sticky) .header-dialog-close-button:after{-webkit-box-flex:0;background-image:url('data:image/svg+xml;utf8,');background-position:50%;background-repeat:no-repeat;content:"";display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-ms-flex:0 0 auto;flex:0 0 auto;height:1.25rem;text-indent:-9999px;width:1.25rem}.cmp-tabs__tablist{display:-webkit-box;display:-ms-flexbox;display:flex;gap:1rem;margin:0 0 1rem}.cmp-tabs__tab{-webkit-box-align:center;-ms-flex-align:center;-webkit-box-pack:center;-ms-flex-pack:center;align-items:center;background:#fff0e4;border:1px solid #f8876b;border-radius:8px;color:#292929;display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;font-family:p22-mackinac-pro,Serif;font-size:1.125rem;font-weight:700;gap:1rem;justify-content:center;margin:0;max-width:-webkit-max-content;max-width:-moz-max-content;max-width:max-content;padding:1rem 2rem;text-decoration:none}.cmp-tabs__tab:hover{background:#fff6ee;color:#292929}.cmp-tabs__tab:active{background:#fff;color:#292929}.cmp-tabs__tab:disabled,.cmp-tabs__tab[aria-disabled=true]{background:#ebeced;color:#70767a}.cmp-tabs__tab:focus,.cmp-tabs__tab:focus-visible{outline:2px solid #0079d1;outline-offset:0}.cmp-tabs__tab:active,.cmp-tabs__tab:hover{border:2px solid #292929}.cmp-tabs__tab:after,.cmp-tabs__tab:hover:after{background-image:url('data:image/svg+xml;utf8,')}.cmp-tabs__tab:active:after{background-image:url('data:image/svg+xml;utf8,')}.cmp-tabs__tab:active:after,.cmp-tabs__tab:after{-webkit-box-flex:0;background-position:50%;background-repeat:no-repeat;content:"";display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-ms-flex:0 0 auto;flex:0 0 auto;height:1em;text-indent:-9999px;width:1em}.cmp-tabs__tab:after{background-image:url('data:image/svg+xml;utf8,')}.cmp-tabs__tab:hover{border:1px solid #f8876b}.cmp-tabs__tab:hover:after{-webkit-box-flex:0;background-image:url('data:image/svg+xml;utf8,');background-position:50%;background-repeat:no-repeat;content:"";display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-ms-flex:0 0 auto;flex:0 0 auto;height:1em;text-indent:-9999px;width:1em}.cmp-tabs__tab--active{background:#fff}.cmp-tabs__tab--active:after{-webkit-box-flex:0;background-image:url('data:image/svg+xml;utf8,');background-position:50%;background-repeat:no-repeat;content:"";display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-ms-flex:0 0 auto;flex:0 0 auto;height:1em;text-indent:-9999px;width:1em}.cmp-tabs__tab:focus{outline:none!important}.cmp-tabs__tabpanel{background:#fff;border:1px solid #f8876b;border-radius:1pc}.cmp-tabs .cmp-alks-common-container-layout-grid-tablet-two-col-50-50>.cmp-container{-webkit-box-align:center;-ms-flex-align:center;-webkit-box-pack:center;-ms-flex-pack:center;align-items:center;justify-content:center}@media screen and (max-width:1024.9px){.cmp-alks-os-tabs-hide-tablet-down{display:none}}.cmp-teaser-text-color-dark-red .cmp-teaser .cmp-teaser__content,.cmp-teaser-text-color-dark-red .cmp-teaser .cmp-teaser__content .cmp-teaser__description,.cmp-teaser-text-color-dark-red .cmp-teaser .cmp-teaser__content .cmp-teaser__description a{color:#8e414c}.cmp-teaser-text-color-black .cmp-teaser .cmp-teaser__content,.cmp-teaser-text-color-black .cmp-teaser .cmp-teaser__content .cmp-teaser__description,.cmp-teaser-text-color-black .cmp-teaser .cmp-teaser__content .cmp-teaser__description a{color:#292929}.cmp-teaser-text-color-white .cmp-teaser .cmp-teaser__content,.cmp-teaser-text-color-white .cmp-teaser .cmp-teaser__content .cmp-teaser__description,.cmp-teaser-text-color-white .cmp-teaser .cmp-teaser__content .cmp-teaser__description a{color:#fff}.cmp-teaser-text-color-navy .cmp-teaser .cmp-teaser__content,.cmp-teaser-text-color-navy .cmp-teaser .cmp-teaser__content .cmp-teaser__description,.cmp-teaser-text-color-navy .cmp-teaser .cmp-teaser__content .cmp-teaser__description a{color:#3a495b}.cmp-teaser-text-color-rose .cmp-teaser .cmp-teaser__content,.cmp-teaser-text-color-rose .cmp-teaser .cmp-teaser__content .cmp-teaser__description,.cmp-teaser-text-color-rose .cmp-teaser .cmp-teaser__content .cmp-teaser__description a{color:#d36954}.cmp-text{color:#292929}.cmp-text-rose .cmp-text{color:#d36954}.cmp-text-white .cmp-text,.cmp-text-white .cmp-text a{color:#fff}.cmp-text-white .cmp-text a:hover{color:#ebeced}.cmp-text-navy .cmp-text{color:#3a495b}.cmp-text-dark-rose .cmp-text{color:#8e414c}.cmp-text ul li::marker{color:#d36954}.cmp-text-bold-rose p b{color:#f8876b}.cmp-text-bold-dark-rose p b{color:#8e414c}.cmp-text-bold-black p b{color:#292929}.cmp-text-underline{color:inherit;max-width:-webkit-fit-content;max-width:-moz-fit-content;max-width:fit-content}.cmp-text-underline,.cmp-text-underline .cmp-text{-webkit-box-orient:vertical;-webkit-box-direction:normal;display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-direction:column;flex-direction:column}.cmp-text-underline .cmp-text{gap:.5rem}.cmp-text-underline .cmp-text:after{border:1px solid;content:"";display:-webkit-box;display:-ms-flexbox;display:flex}.cmp-text-title-color-white h1,.cmp-text-title-color-white h2,.cmp-text-title-color-white h3,.cmp-text-title-color-white h4,.cmp-text-title-color-white h5,.cmp-text-title-color-white h6{color:#fff}.cmp-text-title-color-black h1,.cmp-text-title-color-black h2,.cmp-text-title-color-black h3,.cmp-text-title-color-black h4,.cmp-text-title-color-black h5,.cmp-text-title-color-black h6{color:#292929}.cmp-text-title-color-dark-rose h1,.cmp-text-title-color-dark-rose h2,.cmp-text-title-color-dark-rose h3,.cmp-text-title-color-dark-rose h4,.cmp-text-title-color-dark-rose h5,.cmp-text-title-color-dark-rose h6{color:#8e414c}.cmp-text-title-color-navy h1,.cmp-text-title-color-navy h2,.cmp-text-title-color-navy h3,.cmp-text-title-color-navy h4,.cmp-text-title-color-navy h5,.cmp-text-title-color-navy h6{color:#3a495b}@media screen and (min-width:1025px){.cmp-text-bullet-list-split-desktop ul{-webkit-box-orient:vertical;-webkit-box-direction:normal;display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-direction:column;flex-direction:column;-ms-flex-wrap:wrap;flex-wrap:wrap;max-height:8.5rem}.cmp-text-bullet-list-split-desktop ul li:nth-child(-n+3){margin-right:4rem;max-width:15rem}}.cmp-text-footnote p{font-size:.75rem;font-weight:400;letter-spacing:.01em;line-height:1.5;margin:1em 0}.cmp-text-footnote p:first-child{margin-top:0;padding-top:1em}.cmp-text-footnote p:last-child{margin-bottom:0;padding-bottom:1em}.cmp-text-apply-font-heading *{font-family:p22-mackinac-pro,Serif}.cmp-text-apply-font-body *{font-family:Noto,sans-serif}.cmp-title-color-white{color:#fff}.cmp-title-color-black{color:#292929}.cmp-title-color-dark-red{color:#8e414c}.cmp-title-color-navy{color:#3a495b}.cmp-title-underline{max-width:-webkit-fit-content;max-width:-moz-fit-content;max-width:fit-content}.cmp-title-underline,.cmp-title-underline .cmp-title__text{-webkit-box-orient:vertical;-webkit-box-direction:normal;display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-direction:column;flex-direction:column}.cmp-title-underline .cmp-title__text{gap:.5rem}.cmp-title-underline .cmp-title__text:after{border:1px solid;content:"";display:-webkit-box;display:-ms-flexbox;display:flex}.cmp-title-label h1,.cmp-title-label h2,.cmp-title-label h3,.cmp-title-label h4,.cmp-title-label h5,.cmp-title-label h6{font-family:Noto,sans-serif}.cmp-alks-os-title-section h2{font-size:1rem;font-weight:700}.cmp-container-top-banner{padding-top:2rem}@media screen and (min-width:1025px){.cmp-container-top-banner{padding-top:2.5rem}}.cmp-container-top-banner #top-banner-text-column,.cmp-container-top-banner .cmp-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.cmp-container-top-banner #top-banner-text-column{-webkit-box-orient:vertical;-webkit-box-direction:normal;display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-direction:column;flex-direction:column}@media screen and (min-width:1025px){.cmp-container-top-banner #top-banner-text-column{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}}.cmp-container-top-banner #top-banner-text-column p{font-size:1rem;font-weight:700;letter-spacing:.02rem;line-height:1.5}@media screen and (min-width:1025px){.cmp-container-top-banner #top-banner-text-column p{font-size:1.25rem;font-weight:700;letter-spacing:.025rem;line-height:1.5}}.cmp-container-top-banner #logo-image .cmp-image__image{height:auto;width:18rem}@media screen and (min-width:481px)and (max-width:1024.9px){.cmp-container-top-banner #logo-image .cmp-image__image{width:26rem}}@media screen and (min-width:1025px){.cmp-container-top-banner #logo-image .cmp-image__image{width:24.5rem}}@media screen and (min-width:1401px){.cmp-container-top-banner #logo-image .cmp-image__image{width:35.25rem}}.cmp-container-top-banner .image{-webkit-box-pack:center;-ms-flex-pack:center;justify-content:center}.cmp-container-top-banner .image,.cmp-container-top-banner .image .cmp-image{display:-webkit-box;display:-ms-flexbox;display:flex}.cmp-container-top-banner .image .cmp-image .cmp-image__image{min-height:100%;min-width:100%;-o-object-fit:cover;object-fit:cover}sup{font-size:.75em}